Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE
ABSTRACT For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing.We confirmed that diabetic mice were hypersusceptible to bacteremia caused by Gram-negative bacteria (GNB), dying at inocula nonlethal to nondiabetic mice.Contrary to the pervasive paradigm that diabetes imp